Italy agency cautious on AstraZeneca jab for over 55s
ROME, Jan 31, 2021 (BSS/AFP) – Italy’s medicines agency on Saturday approved
the AstraZeneca coronavirus vaccine for all adults but recommended
alternatives be given to people aged over 55.
AIFA’s decision comes a day after the European Union gave the green light
for the jab, but Germany’s vaccine commission recommended against using it on
older people amid questions over its effectiveness that have been rejected by
“AIFA authorises the AstraZeneca vaccine for the prevention of Covid-19
disease in individuals over the age of 18, as per European Medicines Agency
guidance,” it said.
But it noted “a level of uncertainty” about claims of the jab’s
effectiveness in people over the age of 55, because the age group was “poorly
represented” in trials.
To help with the best use of the vaccine, it recommended “preferential use
of the AstraZeneca vaccine, pending further data, in subjects between 18 and
55 years old, for whom more solid evidence is available”.
It urged the “preferential use of messenger RNA vaccines in older and/or
more frail subjects”.
So-called mRNA vaccines include Pfizer/BioNTech and Moderna jabs, and are
based on a new technology previously untested in a real-world situation.
They use an inert snippet of genetic code from the coronavirus to trigger
an immune response in the body that can repel the active virus.
Many of the other vaccines — including Oxford/AstraZeneca — are variants
of the method used for flu jabs, based on a virus that has been killed and
AstraZeneca earlier rejected German media questioning the vaccine’s
effectiveness in over 65s.
“Reports that the AstraZeneca/Oxford vaccine efficacy is as low as eight
percent in adults over 65 years are completely incorrect,” the firm said in a
statement last Monday.
“In November, we published data in The Lancet demonstrating that older
adults showed strong immune responses to the vaccine, with 100 percent of
older adults generating spike-specific antibodies after the second dose,” it